Methods for detection of horizontal transfer of transposable elements in complete genomes

Genetics and Molecular Biology

Marcos Oliveira De Carvalho¹  Elgion L.s. Loreto¹ 

[1] ,Universidade Federal do Rio Grande do Sul Programa de Pós-Graduação em Genética e Biologia Molecular Porto Alegre RS ,Brazil

关键词: transposable element;    horizontal transfer;    genome;    computational analysis;    evolution;   

DOI  :  10.1590/S1415-47572012000600024

来源: SciELO

【 摘 要 】

Recent advances in nucleic acid sequencing technology are creating a diverse landscape for the analysis of horizontal transfer in complete genomes. Previously limited to prokaryotes, the availability of complete genomes from close eukaryotic species presents an opportunity to validate hypotheses about the patterns of evolution and mechanisms that drive horizontal transfer. Many of those methods can be transported from methods previously used in prokaryotic genomes, as the assumptions for horizontal transfer can be interpreted as the same. Some methods, however, require a complete adaptation, while others need refinements in sensitivity and specificity to deal with the huge datasets generated from next-generation sequencing technologies. Here we list the types of methods used for horizontal transfer detection, as well as theirs strengths and weakness.

【 授权许可】

CC BY   
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