Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon

Genetics and Molecular Biology

Aparecida Maria Fontes²  Simone Kashima²  Ricardo Bonfim-silva²  Rochele Azevedo²  Kuruvilla Joseph Abraham¹  Sérgio Roberto Lopes Albuquerque¹  José Orlando Bordin¹  Dante Mário Langhi Júnior¹  Dimas Tadeu Covas² 

[1] ,Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Instituto Nacional de Ciência e Tecnologia em Células Tronco e Terapia Celular SP ,Brazil

关键词: Brazilian Amazon population;    CR1 haplotypes;    Knops blood group polymorphism;    malaria;   

DOI  :  10.1590/S1415-47572011005000051

来源: SciELO

【 摘 要 】

Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated with susceptibility to Plasmodium falciparum. The odds ratios were reasonably high, suggesting a potentially important association between two Knops blood antigens (Kn b and KAM+) that confer susceptibility to P. falciparum in individuals from the Brazilian Amazon.

【 授权许可】

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