The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population

Genetics and Molecular Biology

Danut Cimponeriu²  Pompilia Apostol¹  Irina Radu²  Anne Marie Craciun¹  Cristian Serafinceanu¹  Mihai Toma²  Cristian Panaite¹  Dan Cheta¹ 

[1] ,University of Bucharest Institute of Genetics Department of Human Genetics and Molecular DiagnosisBucharest,Romania

关键词: Insulin -23Hph;    insulin-like growth factor 2 Apa;    diabetes;    obesity;    case-control study;   

DOI  :  10.1590/S1415-47572010005000074

来源: SciELO

【 摘 要 】

The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups. The -23Hph AA genotype increased the risk for T1DM (OR: 3.22, 95%CI: 2.09-4.98, p < 0,0001), especially in patients without macroalbuminuria (OR: 4.32, 95%CI: 2.54-7.45, p < 0,0001). No other significant association between the alleles or genotypes of insulin -23Hph and IGF2 Apa and diabetes or obesity was identified.

【 授权许可】

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