Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population

Genetics and Molecular Biology

Mahsa M. Amoli²  Parvin Amiri²  Javad Tavakkoly-bazzaz²  Elham Charmchi²  Jila Hafeziyeh²  Mohammad Keramatipour¹  Maryam Abiri¹  Shirin Hasani Ranjbar²  Bagher Larijani² 

[1] ,University of Medical Sciences

关键词: TCF7L2;    gene;    polymorphism;    T2DM;   

DOI  :  10.1590/S1415-47572010005000056

来源: SciELO

【 摘 要 】

The transcription factor 7-like 2 gene (TCF7L2) rs7903146 T allele is constantly associated with Type 2 diabetes in various populations and ethnic groups. Nevertheless, this has not been observed in two studies involving Arab populations. The aim of the present study was to investigate the association between TCF7L2 rs7903146 in an Iranian population. Type 2 diabetes patients (N = 258) and normal healthy control subjects (N = 168) from the same area, were examined. The ARMS-PCR (Amplification Refractory Mutation System) technique, subsequently validated by direct sequencing, was used for genotyping. Allele and genotype frequencies were significantly different between patients and controls TT vs. CT + CC [p 0.0081 OR 3.4 95%CI (1.27-11.9)] and T vs. C allele [p 0.02 OR 1.4 95%CI (1.03-1.9)]. Our data thus confirm the association between the rs7903146 T allele and T2D in an Iranian population, contrary to previous reports in Arab populations. This can possibly be attributed to differences in ethnic background or the effects of environmental factors.

【 授权许可】

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