Association of IGF-I gene polymorphisms with milk yield and body size in Chinese dairy goats

Genetics and Molecular Biology

Chanjuan Deng¹  Rongnuan Ma¹  Xiangpeng Yue¹  Xianyong Lan¹  Hong Chen¹  Chuzhao Lei¹ 

[1] ,Northwest A & F University,China

关键词: IGF-I gene;    dairy goat;    milk yield;    PCR- SSCP;   

DOI  :  10.1590/S1415-47572010005000034

来源: SciELO

【 摘 要 】

The association of IGF-I gene polymorphisms with certain traits in 708 individuals of two Chinese dairy-goat breeds (Guanzhong and Xinong Saanen) was investigated. Polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and DNA sequencing methods were employed in screening for genetic variation. Two novel mutations were detected in the 5'-flanking region and in intron 4 of IGF-I gene, viz., g.1617 G > A and g.5752 G > C (accession D26119.2), respectively. The associations of the g.1617 G > A mutation with milk yield and the body size were not significant (p > 0.05). However, in the case of g.5752 G > C, Xinong Saanen dairy goats with the CG genotype presented longer bodies (p < 0.05). Chest circumference (p < 0.05) was larger in Guanzhong goats with the GG genotype. In Xinong Saanen dairy goats with the CC genotype, milk yields were significantly higher during the first and second lactations (p < 0.05). Hence, the g.5752 G > C mutation could facilitate association analysis and serve as a genetic marker for Chinese dairy-goat breeding and genetics.

【 授权许可】

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