NS3 protease from flavivirus as a target for designing antiviral inhibitors against dengue virus

Genetics and Molecular Biology

Satheesh Natarajan¹ 

[1] ,University of Malaya Faculty of Medicine Department of BiochemistryKuala Lumpur,Malayasia

关键词: antiviral inhibitor;    drug discovery;    multifunctional protein;    NS3;    protease;   

DOI  :  10.1590/S1415-47572010000200002

来源: SciELO

【 摘 要 】

The development of novel therapeutic agents is essential for combating the increasing number of cases of dengue fever in endemic countries and among a large number of travelers from non-endemic countries. The dengue virus has three structural proteins and seven non-structural (NS) proteins. NS3 is a multifunctional protein with an N-terminal protease domain (NS3pro) that is responsible for proteolytic processing of the viral polyprotein, and a C-terminal region that contains an RNA triphosphatase, RNA helicase and RNA-stimulated NTPase domain that are essential for RNA replication. The serine protease domain of NS3 plays a central role in the replicative cycle of dengue virus. This review discusses the recent structural and biological studies on the NS2B-NS3 protease-helicase and considers the prospects for the development of small molecules as antiviral drugs to target this fascinating, multifunctional protein.

【 授权许可】

CC BY   
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