Association between MUC1 gene polymorphism and expected progeny differences in Nelore cattle (Bos primigenius indicus)

Genetics and Molecular Biology

Fabio Ricardo Pablos De Souza²  Pedro Alejandro Vozzi²  Reginaldo Aparecido Vila²  Arione Augusti Boligon¹  Marli Aparecida Vani Galerani²  Raysildo Barbosa Lobo²  Lucia Regina Martelli² 

[1] ,Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de GenéticaRibeirão Preto SP ,Brazil

关键词: beef cattle;    molecular marker;    productive traits;    quantitative trait locus;   

DOI  :  10.1590/S1415-47572009005000098

来源: SciELO

【 摘 要 】

MUC1 is a heavily glycosylated mammalian transmembrane protein expressed by mucosal secretory tissues for both protection against microbial infection and lubrication. An important characteristic of MUC1 is its variable number of tandem repeats (VNTR) containing several sites for O-glycosylation. VNTR length has been associated with many human diseases and with certain economically important traits in domestic ruminants. The aim of the present study was to correlate the length of MUC1 gene VNTR with expected progeny differences (EPDs) obtained for growth, fertility and carcass traits. Five alleles were identified, with alleles containing short VNTRs being more frequent than those with long, thereby demonstrating that Brazilian Nelore cattle are characterized by high frequencies in short MUC1 VNTRs. Statistical analyses revealed there to be no significant association between VNTR length and EPDs for weight at 120 days (W120), scrotal circumference at 365 (SC365) and 450 (SC450) days, age at first calving (AFC), and rib eye area (REA).

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License