Genetics and Molecular Biology | |
Expression of Msx1 and Dlx1 during Dumbo rat head development: correlation with morphological features | |
Suhair Katerji2  Nathalie Vanmuylder2  Michal Svoboda1  Marcel Rooze2  Stéphane Louryan2  | |
[1] ,Université Libre de Bruxelles Faculté de Médecine Laboratory of Anatomy and EmbryologyBrussels Belgium | |
关键词: Dumbo rat; Msx1; Dlx1; face; embryo; development; | |
DOI : 10.1590/S1415-47572009005000041 | |
来源: SciELO | |
【 摘 要 】
The Dumbo rat possesses some characteristics that evoke several human syndromes, such as Treacher-Collins: shortness of the maxillary, zygomatic and mandibular bones, and low position of the ears. Knowing that many homeobox genes are candidates in craniofacial development, we investigated the involvement of the Msx1 and Dlx1 genes in the Dumbo phenotype with the aim of understanding their possible role in abnormal craniofacial morphogenesis and examining the possibility of using Dumbo rat as an experimental model for understanding abnormal craniofacial development. We studied the expression of these genes during craniofacial morphogenesis by RT-PCR method. We used Dumbo embryos at E12 and E14 and included the Wistar strain as a control. Semi-quantitative PCR analysis demonstrated that Msx1 and Dlx1 are expressed differently between Dumbo and Wistar rats, indicating that their low expression may underly the Dumbo phenotype.
【 授权许可】
CC BY
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