Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris

Genetics and Molecular Biology

Lin Gao¹  Hong Li¹  Kai Li¹  Zhu Shen¹  Ling Liu¹  Chunying Li¹  Zhengdong Zhang¹  Yufeng Liu¹ 

关键词: COMT;    gene polymorphism;    genetic susceptibility;    psoriasis;   

DOI  :  10.1590/S1415-47572009005000002

来源: SciELO

【 摘 要 】

Psoriasis vulgaris is defined by a series of linked cellular changes in the skin: hyperplasia of epidermal keratinocytes, vascular hyperplasia and ectasia, and infiltration of T lymphocytes, neutrophils and other types of leukocytes in the affected skin. Catechol-O-methyltransferase ( COMT )158polymorphism can reduce the activity of the COMT enzyme that may trigger defective differentiation of keratinocytes in psoriasis. Immunocytes can degrade and inactivate catecholamines via monamine oxidase (MAO) and COMT in the cells. We hypothesized that theCOMT-158G>Apolymorphism was associated with the risk of psoriasis vulgaris in Han Chinese people. In a hospital-based case-control study, 524 patients with psoriasis vulgaris and 549 psoriasis-free controls were studied.COMT-158 G>Apolymorphism was genotyped using the PCR sequence-specific primer (PCR-SSP) technique. We found no statistically significant association between theCOMT-158alleleAand the risk of psoriasis vulgaris (p = 0.739 adjusted OR = 1.03; 95% CI = 0.81-1.31). This suggests that theCOMT-158 G>Apolymorphism may not contribute to the etiology of psoriasis vulgaris in the Han Chinese population.

【 授权许可】

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