MTHFR , prothrombin and Factor V gene variants in Turkish patients with coronary artery stenosis

Genetics and Molecular Biology

Müge Caner¹  Rifat Bircan¹  Deniz Sevinç¹  Fehime Benli¹  A. Ilter Güney¹  Nuri Kurtoglu¹ 

关键词: genetic polymorphism;    coronary disease;    MTHFR gene;    prothrombin gene;    Factor V gene;   

DOI  :  10.1590/S1415-47572008005000023

来源: SciELO

【 摘 要 】

Many epidemiological studies have reported an association between hemostatic factors and risk of both coronary and peripheral artery diseases. Using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis, we investigated the association between coronary artery disease and polymorphisms in the methylenetetrahydrofolate reductase ( MTHFRC677T and A1298C), prothrombin (G20210A), and factor V (A4070G) genes. We screened these gene variants in 174 subjects who had undergone coronary angiography - 115 patients with patent coronary artery disease (grade 3 vessel disease,i.e. , significant coronary stenosis), and 59 healthy controls with grade 0 vessel disease. The analysis of our data did not show any statistically significant association between coronary artery disease (CAD) and the investigated polymorphisms.

【 授权许可】

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