Genetic polymorphisms at the leptin receptor gene in three beef cattle breeds

Genetics and Molecular Biology

Sabrina E.m. Almeida²  Luciana B.s. Santos¹  Daniel T. Passos¹  Ângela O. Corbellini¹  Beatriz M.t. Lopes²  Cláudia Kirst²  Gustavo Terra¹  Jairo P. Neves¹  Paulo B.d. Gonçalves¹  José C.f. Moraes¹  Tania De Azevedo Weimer¹ 

[1] ,Universidade Federal do Rio Grande do Sul Departamento de Genética Porto Alegre RS ,Brazil

关键词: molecular markers;    genetic diversity;    cattle production;    LEPR gene polymorphisms;   

DOI  :  10.1590/S1415-47572008000400013

来源: SciELO

【 摘 要 】

The genetic diversity of a single nucleotide polymorphism (SNP) at the exon 20 (T945M) of the leptin receptor gene (LEPR) and of three short tandem repeats (STRs BM7225, BMS694, and BMS2145) linked to LEPR was investigated in three beef cattle herds (Brangus Ibagé, Charolais, and Aberdeen Angus). A cheap and effective new method to analyze the T945M polymorphism in cattle populations was developed and the possible role of these polymorphisms in reproduction and weight gain of postpartum cows was evaluated. High levels of genetic diversity were observed with the average heterozygosity of STRs ranging from 0.71 to 0.81. No significant association was detected between LEPR markers and reproductive parameters or daily weight gain. These negative results suggest that the LEPR gene polymorphisms, at least those herein described, do not influence postpartum cows production.

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