In search of essentiality: Mollicute-specific genes shared by twelve genomes

Genetics and Molecular Biology

Rangel Celso Souza²  Darcy Fontoura De Almeida¹  Arnaldo Zaha¹  David Anderson De Lima Morais²  Ana Tereza Ribeiro De Vasconcelos² 

[1] ,Laboratório Nacional de Computação CientíficaPetropólis RJ ,Brazil

关键词: mollicutes;    comparative genomics;    synteny;    bidirectional best hit;   

DOI  :  10.1590/S1415-47572007000200002

来源: SciELO

【 摘 要 】

Mollicutes are cell wall-less bacteria with a genome characterized by its small size. Chromosomal rearrangements help these organisms evade host immune surveillance and hence cause disease. Our goal was to determine genes shared by Mollicutes genomes using the bidirectional best hit methodology. The twelve studied Mollicutes share 210 genes, most of which (> 60%) fall into the following COG categories: translation, ribosomal structure and biogenesis; DNA replication, recombination and repair; nucleotide transport and metabolism and energy production and conversion. Thirty Mollicute-specific genes were identified, 22 of them previously described as essential genes in Mycoplasma genitalium.

【 授权许可】

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