Absence of mutagenicity in somatic and germ cells of mice submitted to subchronic treatment with an extract of Croton cajucara Benth. (Euphorbiaceae)

Genetics and Molecular Biology

Fabio V. Santos²  Suzana F.p. Mesquita²  Maria José S.s. Faria²  Aline Poersh²  Maria Aparecida M. Maciel¹  Angelo C. Pinto¹  Helena K. Morimoto¹  Ilce Mara S. Cólus² 

[1] ,Universidade Estadual de Londrina Centro de Ciências Biológicas Departamento de Biologia GeralLondrina Paraná ,Brazil

关键词: antimutagenicity;    mutagenicity;    dominant lethal;    micronucleus;    Croton cajucara;    medicinal plant;   

DOI  :  10.1590/S1415-47572006000100029

来源: SciELO

【 摘 要 】

The plant Croton cajucara Benth. (Euphorbiaceae) is a medicinal plant from the Brazilian Amazon where it is commonly known as sacaca. The principal compound isolated from C. cajucara stem-bark extracts is the clerodane-type diterpene trans-dehydrocrotonin (DCTN) which presents several biological activities, including antiulcerogenic, anti-inflammatory, hypoglycemic, antimutagenic and antitumoral activity. However, few studies have been carried out to evaluate the therapeutic potential of raw C. cajucara extracts. We studied mutagenicity and antimutagenicity effects of C. cajucara methanol extract using the micronucleus assay in bone marrow cells and the dominant lethal assay in mice submitted to subchronic treatments. The blood testosterone levels of the mice were also measured to assess the effects of the methanol extract on testes function. Statistical analysis of the data obtained in this study showed no statistically significant mutagenicity attributable to C. cajucara stem-bark extracts, nor did such extracts show antimutagenic activity at the concentrations assessed. The testosterone concentration was normal in all the mice studied.

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