Patterns of molecular evolution in pathogenesis-related proteins

Genetics and Molecular Biology

Nicole M. Scherer²  Claudia E. Thompson²  Loreta B. Freitas²  Sandro L. Bonatto¹  Francisco M. Salzano² 

[1] ,Universidade Federal do Rio Grande do Sul Instituto de Biociências Departamento de GenéticaPorto Alegre RS ,Brazil

关键词: pathogenesis-related proteins;    PRs;    molecular variability;    positive selection;    maximum-likelihood methods;   

DOI  :  10.1590/S1415-47572005000500001

来源: SciELO

【 摘 要 】

The genes encoding 13 classes of pathogenesis-related (PR) proteins were examined for positive selection using maximum-likelihood (ML) models of codon substitution. The study involved 194 sequences from 54 species belonging to 37 genera. Although the sizes of the sequences examined varied from 237 bp for PR12 to 1,110 bp for PR7, most classes (9 out of 13) contained sequences made up of more than 400 nucleotides. Signs of positive selection were obtained for sites in PR proteins 4, 6, 8, 9 and 15 using an ML-based Bayesian method and likelihood ratio tests. These results confirm the importance of positive selection in proteins related to defense mechanisms already observed in a wide array of organisms.

【 授权许可】

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