Effects of H2O2, Fe2+ and Fe3+ on curcumin-induced chromosomal aberrations in CHO cells

Genetics and Molecular Biology

Lusânia Maria Greggi Antunes²  Maria Cristina Paiva Araújo¹  Francisca Da Luz Dias²  Catarina Satie Takahashi¹ 

[1] ,Faculdade de Medicina do Triângulo Mineiro Departamento de Ciências Biológicas Uberaba MG ,Brazil

关键词: CHO;    chromosomal aberrations;    curcumin;    hydrogen peroxide;    mutagenesis;   

DOI  :  10.1590/S1415-47572005000100028

来源: SciELO

【 摘 要 】

The effects of H2O2, Fe2+ and Fe3+ on curcumin-induced clastogenicity were evaluated in CHO cells. Curcumin combined with H2O2 did not increase the chromosomal aberrations more than expected based on a simple additive effect. In contrast, the combination of curcumin-Fe significantly decreased the total number of chromosomal aberrations and the number of abnormal metaphases. The clastogenicity of curcumin may be related to its pro-oxidant properties and its ability to generate free radicals.

【 授权许可】

CC BY   
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