GATM, the human ortholog of the mouse imprinted Gatm gene, escapes genomic imprinting in placenta

Genetics and Molecular Biology

Toshinobu Miyamoto²  Kazuo Sengoku²  Hiroaki Hayashi²  Yoshihito Sasaki²  Yoshihiro Jinno¹  Mutsuo Ishikawa² 

[1] ,Asahikawa Medical College Department of Obstetrics and Gynecology Asahikawa Hokkaido ,Japan

关键词: GATM gene;    genomic imprinting;    DNA polymorphism;   

DOI  :  10.1590/S1415-47572005000100008

来源: SciELO

【 摘 要 】

The GATM gene encodes L-arginine:glycine amidinotransferase, which catalyzes the conversion of L-arginine into guanidinoacetate, the rate-limiting step in the synthesis of creatine. Since, deficiencies in creatine synthesis and transport lead to certain forms of mental retardation in human, the human GATM gene appears to be involved in brain development. Recently it has been demonstrated that the mouse Gatm is expressed during development and is imprinted with maternal expression in the placenta and yolk sac, but not in embryonic tissues. We investigated the imprinting status of the human GATM by analyzing its expression in four human placentas. GATM was biallelically expressed, thus suggesting that this gene escapes genomic imprinting in placentas, differently from what has been reported in mouse extra-embryonic tissues.

【 授权许可】

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