Prevalence of high-risk human papillomavirus by cobas 4800 HPV test in urban Peru

Brazilian Journal of Infectious Diseases

Ricardo Iwasaki¹  Felipe Galvez-philpott¹  Javier Arias-stella Jr.¹  Javier Arias-stella¹ 

关键词: High-risk human papillomavirus;    Prevalence;    Cobas 4800 HPV test;   

DOI  :  10.1016/j.bjid.2014.01.010

来源: SciELO

【 摘 要 】

Background:Molecular tests allow the detection of high-risk human papillomavirus in cervical samples, playing an important role in the prevention of cervical cancer.Objectives:We performed a study to determine the prevalence of HPV 16, HPV 18 and other high-risk human papillomavirus (pool 12 genotypes) in Peruvian females from diverse urban areas using the cobas 4800 HPV test.Methods:Routine cervical samples collected in our laboratory were analyzed by cobas 4800 HPV test.Results:A total of 2247 samples from female patients aged 17–79 years were tested. high-risk human papillomavirus was positive in 775 (34.49%) samples. Of these, 641 (82.71%) were single infections and 134 (17.29%) were multiple infections. The positivity rates for HPV 16, HPV 18, and other high-risk human papillomavirus were 10.77%, 2.0%, and 28.08%, respectively. In multiple high-risk human papillomavirus infections, the concomitance of HPV 16 and other high-risk human papillomavirus was more prevalent (13.42%).Conclusion:Our study showed high prevalence of high-risk human papillomavirus in urban Peru, mainly among young women. In both single and multiple infections other high-risk human papillomavirus were more prevalent than HPV 16 and HPV 18, which might influence vaccine impact in our country. Furthermore, the cobas 4800 HPV test may be considered a useful tool for HPV molecular diagnosis.

【 授权许可】

CC BY-NC-ND   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License