The incidence of cytomegalovirus infection in lung transplant recipients under universal prophylaxis with intravenous ganciclovir

Brazilian Journal of Infectious Diseases

Regina Schröeder²  Tatiana Michelon²  João Wurdig²  Iara Fagundes²  Sadi Schio¹  Leticia Sanchez¹  José J. Camargo¹  Teresa C. Sukkienik¹  Alessandro C. Pasqualotto¹  Jorge Neumann² 

[1] ,Santa Casa Complexo Hospitalar Laboratory of Transplant Immunology Porto Alegre,Brazil

关键词: Cytomegalovirus;    antigenemia;    lung transplantation;    ganciclovir;    prophylaxis;   

DOI  :  10.1590/S1413-86702007000200008

来源: SciELO

【 摘 要 】

The best strategy for control of cytomegalovirus (CMV) infection in lung transplant patients is still not determined. The aim of this study was to document the incidence of CMV infection in a cohort of lung transplant recipients under universal prophylaxis with intravenous ganciclovir. All patients received immunosuppressive regimens consisting of cyclosporine, azathioprine, and prednisone. Regardless of CMV serostatus, intravenous ganciclovir was prescribed for every patient in the first 3 months post-transplantation. CMV infection was defined as the detection of CMV pp65 in leukocytes. Eighty-two lung transplant patients were included over a 5-year period. The incidence of CMV infection in the first year post-transplantation was 68.3%, occurring after a median length of 114 days (range, 26-343 days). This study revealed a high incidence of CMV infection in the first year following lung transplantation despite prolonged universal ganciclovir prophylaxis.

【 授权许可】

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