Viral hepatitis in patients infected with human immunodeficiency virus

Brazilian Journal of Infectious Diseases

Maria Helena P. Pavan¹  Francisco Hideo Aoki¹  Dinaida Teresa Monteiro¹  Neiva Sellan L. Gonçales¹  Cecília Amélia F. Escanhoela¹  Fernando L. Gonçales Júnior¹ 

[1] ,UNICAMP Faculty of Medecine Hematology and Hemoterapy CentreCampinas São Paulo ,Brazil

关键词: Hepatitis C virus;    human immunodeficiency virus;    alanine aminotransferase quotient;    anti-hepatitis A antibody;    hepatitis B surface antigen;    anti-hepatitis B core antigen (anti-HBc);   

DOI  :  10.1590/S1413-86702003000400005

来源: SciELO

【 摘 要 】

From 1992 to 1995 we studied 232 (69% male, 87% Caucasian) anti-human immunodeficiency virus (anti-HIV) positive Brazilian patients, through a questionnaire; HIV had been acquired sexually by 50%, from blood by 32%, sexually and/or from blood by 16.4% and by an unknown route by 1.7%. Intravenous drug use was reported by 29%; it was the most important risk factor for HIV transmission. The alanine aminotransferase quotient (qALT) was >1 for 40% of the patients, 93.6% had anti-hepatitis A virus antibody, 5.3% presented hepatitis B surface antigen, 44% were anti-hepatitis B core antigen positive and 53.8% were anti-hepatitis C virus (anti-HCV) positive. The anti-HCV test showed a significant association with qALT>1. Patients for whom the probable HIV transmission route was blood had a 10.8 times greater risk of being anti-HCV positive than patients infected by other routes. Among 30 patients submitted to liver biopsy, 18 presented chronic hepatitis.

【 授权许可】

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