Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses

Ciência & Saúde Coletiva

Mark J. Nieuwenhuijsen²  David Martinez²  James Grellier¹  James Bennett¹  Nicky Best¹  Nina Iszatt¹  Martine Vrijheid²  Mireille B. Toledano¹ 

[1] ,Centre for Research in Environmental EpidemiologyBarcelona,Spain

关键词: Birth defects;    Congenital anomalies;    Disinfection by-products;    Fetal development;    Reproductive health;    Trihalomethanes;    Defeitos congênitos;    Anomalias congênitas;    Subprodutos da desinfecção;    Desenvolvimento fetal;    Saúde reprodutiva;    Trihalometano;   

DOI  :  10.1590/S1413-81232010000800015

来源: SciELO

【 摘 要 】

This study aims to review epidemiologic evidence of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies. All epidemiologic studies that evaluated a relationship between an index of DBP exposure and risk of congenital anomalies were analyzed. For all congenital anomalies combined, the meta-analysis gave a statistically significant excess risk for high versus low exposure to water chlorination or TTHM (17%; 95% CI, 3-34) based on a small number of studies. The meta-analysis also suggested a statistically significant excess risk for ventricular septal defects (58%; 95% CI, 21-107), but based on only three studies, and there was little evidence of an exposure-response relationship. It was observed no statistically significant relationships in the other meta-analyses and little evidence for publication bias, except for urinary tract defects and cleft lip and palate. Although some individual studies have suggested an association between chlorination disinfection by-products and congenital anomalies, meta-analyses of all currently available studies demonstrate little evidence of such association.

【 授权许可】

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