Understanding the type 1 reactional state for early diagnosis and treatment: a way to avoid disability in leprosy

Anais Brasileiros de Dermatologia

Jose Augusto Da Costa Nery¹  Fred Bernardes Filho¹  Juliana Quintanilha¹  Alice Miranda Machado¹  Soraya De Souza Chantre Oliveira¹  Anna Maria Sales¹ 

关键词: Erythema nodosum;    Leprosy;    Leprosy;    multibacillary;    Leprosy;    paucibacillary;    Mycobacterium leprae;    Eritema nodoso;    Hanseniase;    Hanseniase multibacilar;    Hanseniase paucibacilar;    Mycobacterium leprae;   

DOI  :  10.1590/abd1806-4841.20132004

来源: SciELO

【 摘 要 】

A type 1 reaction or reversal reaction is expressed clinically by inflammatory exacerbation of the skin lesions and nerve trunks, consequently leading to sensory and motor alterations. It occurs in non-polar forms of leprosy, although it can occur in a small percentage of sub-polar LL treated patients. Disabilities, deformities and morbidity, still present in leprosy, are mainly caused by these acute episodes. The recognition of reactional states is imperative for an early approach and efficient management, to avoid the emergence of disabilities that stigmatize the disease. This review aims to describe the clinical aspects, immunopathogenesis, epidemiology, histopathological features and therapeutics of type 1 reactions.

【 授权许可】

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