Desmoplastic melanoma associated with an intraepidermal lentiginous lesion: case report and literature review

Anais Brasileiros de Dermatologia

Cesar De Souza Bastos Junior¹  Juan Manuel Pineiro-maceira¹  Fernando Manuel Belles De Moraes¹ 

关键词: Melanoma;    Nevus;    epithelioid and spindle cell;    S100 Proteins;    WT1 Protein;    Melanoma;    Nevo de celulas epitelioides e fusiformes;    Proteinas S100;    Proteinas WT1;   

DOI  :  10.1590/abd1806-4841.20131817

来源: SciELO

【 摘 要 】

Desmoplastic melanoma tends to present as firm, amelanotic papules. Microscopically, it reveals a proliferation of fusiform cells in the dermis and variable collagen deposition, as well as intraepidermal melanocytic proliferation of lentiginous type in most cases. Biopsy in a 61-year-old white male patient, who had received a diagnosis of lentigo maligna on his face 10 years before, revealed a proliferation of dermal pigmented spindle cells and collagen deposition, reaching the deep reticular dermis, with a lentiginous component. Immunohistochemistry with S-100, Melan-A and WT1 showed positivity, but it was weak with HMB45. Desmoplastic melanoma associated with lentigo maligna was diagnosed. Several authors discuss whether desmoplastic melanoma represents a progression from the lentiginous component or arises "de novo". Desmoplastic melanoma represents a minority of cases of primary cutaneous melanoma (less than 4%). Identification of lentigo maligna indicates that desmoplastic melanoma should be carefully investigated.

【 授权许可】

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