Mucormycosis and chromoblastomycosis occurring in a patient with leprosy type 2 reaction under prolonged corticosteroid and thalidomide therapy

Anais Brasileiros de Dermatologia

Flávia Machado Alves Basílio²  Mariana Hammerschmidt²  Maira Mitsue Mukai²  Betina Werner²  Rosângela Lameira Pinheiro¹  Sandra Moritz¹ 

[1] ,Federal University of ParanáCuritiba PR ,Brazil

关键词: Chromoblastomycosis;    Immunocompromised host;    Leprosy;    Mucormycosis;    Cromoblastomicose;    Hanseníase;    Hospedeiro imunocomprometido;    Mucormicose;   

DOI  :  10.1590/S0365-05962012000500017

来源: SciELO

【 摘 要 】

Mucormycosis is an uncommon fungal infection caused by Mucorales. It frequently occurs in patients with neutropenia, diabetes, malignancy and on corticoid therapy. However, it is rare in patients with AIDS. Clinical disease can be manifested in several forms. The case reported illustrates the rare occurrence of chromoblastomycosis and mucormycosis in an immunosuppressed patient with multibacillary leprosy, under prolonged corticosteroid and thalidomide therapy to control leprosy type 2 reaction. Neutrophil dysfunction, thalidomide therapy and work activities are some of the risk factors in this case. Chromoblastomycosis was treated by surgical excision and mucormycosis with amphotericin B. Although the prognosis of mucormycosis is generally poor, in the reported case the patient recovered successfully. This case should alert dermatologists to possible opportunistic infections in immunosuppressed patients.

【 授权许可】

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