Nephrogenic systemic fibrosis: concepts and perspectives

Anais Brasileiros de Dermatologia

Ana Carolina De Souza Machado Igreja²  Kleyton De Carvalho Mesquita¹  Shawn Edwin Cowper¹  Izelda Maria Carvalho Costa¹ 

[1] ,UnB Hospital Universitário de Brasília Brasília Federal District ,Brazil

关键词: Contrast media;    Gadolinium;    Magnetic resonance imaging;    Nephrogenic fibrosing dermopathy;    Renal insufficiency;    Dermopatia fibrosante nefrogênica;    Gadolínio;    Imagem por ressonância magnética;    Insuficiência renal;    Meios de contraste;   

DOI  :  10.1590/S0365-05962012000400013

来源: SciELO

【 摘 要 】

Nephrogenic systemic fibrosis is a chronic, progressive condition that develops in some patients with renal impairment after exposure to gadolinium-based contrast agents used in magnetic resonance imaging. Thickening of the skin is typical, usually affecting the extremities. Visceral organs can also be affected. The diagnosis of the disease requires careful clinicopathological correlation. Treatment aims at restoring renal function, which is associated with delayed progression and, eventually, remission of skin changes. Reduction and prevention of nephrogenic systemic fibrosis cases are based on limiting the use of gadolinium-based contrast agents in patients with kidney disorders (especially in patients with advanced renal failure at stages 4 and 5), and restricting their use to situations in which they are essential to diagnosis/follow-up. Other than limiting exposure to gadolinium based contrast agents, no effective preventive methods have been reported. Due to increased awareness about the disease among radiologists and nephrologists, the incidence of nephrogenic systemic fibrosis is declining.

【 授权许可】

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