HLA among Brazilian patients with spontaneous chronic urticaria and positive autologous serum skin test

Anais Brasileiros de Dermatologia

Zamir Calamita²  Andrea Bronhara Pelá²  Márcia Gamberini¹  Wilson Baleotti Júnior¹  Odilon Marques De Almeida Filho²  Marcelo O. Ruiz¹  Dione G. Arevalo¹  Antônio Fabron Júnior¹ 

[1] ,Faculdade Estadual de Medicina de MaríliaMarília SP ,Brazil

关键词: Genes;    MHC class I;    Genes;    MHC class II;    HLA antigens;    Skin tests;    Urticaria;    Antígenos HLA;    Genes Classe I do Complexo de Histocompatibilidade (MHC);    Genes Classe II do Complexo de Histocompatibilidade (MHC);    Testes Cutâneos;    Urticária;   

DOI  :  10.1590/S0365-05962012000400010

来源: SciELO

【 摘 要 】

BACKGROUND: An association between class I and II alleles of the major histocompatibility complex and idiopathic chronic urticaria has previously been observed in different populations, but there are still no studies on Brazilian populations in this regard. OBJECTIVE: The involvement of the major histocompatibility complex classes I and II (loci A, B and DR) in Brazilian patients with idiopathic chronic urticaria and a positive autologous serum skin test was investigated and compared with a healthy population group. METHODS: DNA was extracted from the blood of 42 patients with idiopathic chronic urticaria and major histocompatibility complex classes I and II alleles were determined using the polymerase chain reaction and a laboratory test for oligonucleotide hybridization using a single-filament probe. The frequencies of these alleles in patients with chronic urticaria were compared with the frequencies in 1000 genetically unrelated voluntary blood donors from the same region of Brazil. The diagnosis of idiopathic chronic urticaria was based on the patients' clinical history and routine laboratory tests. Only the patients with positive autologous serum skin test were selected. The allele distribution resulted from the patient and control groups were analyzed using odds ratios and 95% confidence intervals. RESULTS: No statistically significant differences were found between the positive autologous serum skin test patients with chronic urticaria and the control group. CONCLUSIONS: We found that in this population group, there was no specific association between the HLA alleles studied and chronic urticaria. We believe that further population studies are needed in order to investigate the possible existence of this association.

【 授权许可】

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