Pain in photodynamic therapy: mechanism of action and management strategies

Anais Brasileiros de Dermatologia

Yuri Nogueira Chaves¹  Luis Antônio Torezan¹  Ane Beatriz Mautari Niwa¹  José Antônio Sanches Junior¹  Ciro Festa Neto¹ 

[1] ,University of Sao Paulo School of Medicine Department of DermatologySao Paulo SP ,Brazil

关键词: Pain;    referred;    Photochemotherapy;    Photosensitizing agents;    Agentes fotossensibilizantes;    Dor referida;    Fotoquimioterapia;   

DOI  :  10.1590/S0365-05962012000400001

来源: SciELO

【 摘 要 】

Photodynamic therapy involves administration of a photosensitizing drug and its subsequent activation by irradiation with a light source at wavelengths matching the absorption spectrum of the photosensitizer. In many countries around the world, topical photodynamic therapy has been approved for treatment of cutaneous oncologic conditions such as actinic keratosis, Bowen's disease, and superficial basal cell carcinoma. Multicenter, randomized, controlled studies have confirmed its efficacy and superior cosmetic outcomes compared to conventional therapies. Nevertheless, this therapeutic method presents some adverse effects, such as erythema, edema, pigmentation, pustules, and pain. There is no doubt that pain is the most severe of the adverse effects, being sometimes responsible for definitive treatment interruption. The pain mechanism has not yet been fully understood, which makes complete pain control a challenge to be conquered. In spite of that, this literature review presents some useful pain management strategies as well as the most important pain-related factors in photodynamic therapy.

【 授权许可】

CC BY-NC   
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