Topical (S)-ketamine for pain management of postherpetic neuralgia

Anais Brasileiros de Dermatologia

Guilherme Antonio Moreira De Barros¹  Hélio Amante Miot²  Ademir Massarico Braz²  Flávia Ramos²  Marcos Aristoteles Borges² 

[1] ,Universidade Estadual Paulista Julio de Mesquita Filho School of Medicine of Botucatu Department of AnesthesiologyBotucatu SP ,Brazil

关键词: administration;    topical;    ketamine;    neuralgia;    postherpetic;    administração tópica;    ketamina;    neuralgia pós-herpética;   

DOI  :  10.1590/S0365-05962012000300032

来源: SciELO

【 摘 要 】

Herpes zoster infection may cause postherpetic neuralgia, which is defined by prolonged pain predominantly mediated by central nervous system hypersensitivity. This phenomenon may be reversed by (S)-ketamine (SKET), but its use results in intolerable side effects, while its topical administration seems to be safe. It is a cross-over design study with 12 patients randomly divided into two groups. There was a significant effect of time on pain intensity, but no statistical difference in pain scores for SKET or placebo use in this sample in this treatment regimen. Only few mild cutaneous reactions were observed with topical SKET use.

【 授权许可】

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