Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects

Anais Brasileiros de Dermatologia

Renata Aparecida Martinez Antunes Ribeiro Vieira²  Eliana Maria Minicucci²  Mariangela Esther Alencar Marques¹  Silvio Alencar Marques¹ 

[1] ,Universidade Estadual Paulista Júlio de Mesquita Filho Medical School of Botucatu Department of Dermatology and RadiotherapySao Paulo SP ,Brazil

关键词: Carcinoma;    squamous cell;    Cheilitis;    Cyclin-dependent kinase inhibitor proteins;    Cyclin D1;    Protooncogene proteins c-bcl-2;    Tumor suppressor protein p53;    Carcinoma de células escamosas;    Ciclina D1;    Proteína supressora de tumor p53;    Proteínas inibidoras de quinase dependente de ciclina;    Proteínas Proto-oncogênicas c-bcl-2;    Queilite;   

DOI  :  10.1590/S0365-05962012000100013

来源: SciELO

【 摘 要 】

Actinic cheilitis is the main precancerous lesion of the lip. Squamous cell carcinoma of the lip is reported together with oral carcinomas in the Brazilian official statistics. Overall, they account for 40% of the head and neck carcinomas. In general, physicians and dentists know little about what causes oral tumor development and progression. Tumor suppressor genes and cell proliferation regulatory proteins play a role in the progression of actinic cheilitis to squamous cell carcinoma and in its biological behavior. Knowledge on prognostic and diagnostic markers has a positive impact on the follow-up of these patients.

【 授权许可】

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