The vegetal biomembrane in the healing of chronic venous ulcers

Anais Brasileiros de Dermatologia

Marco Andrey Cipriani Frade²  Raimunda Violante Campos De Assis¹  Joaquim Coutinho Netto¹  Thiago Antônio Moretti De Andrade¹  Norma Tiraboschi Foss² 

[1] ,Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Department of Internal Medicine

关键词: Biological dressings;    Latex;    Leg ulcer;    Wound healing;    Cicatrização;    Curativos biológicos;    Látex;    Úlcera da perna;   

DOI  :  10.1590/S0365-05962012000100005

来源: SciELO

【 摘 要 】

BACKGROUND: The vegetal biomembrane has been used to treat cutaneous ulcers. OBJECTIVES: To assess the role of the vegetal biomembrane on the chronic venous ulcers treatment compared to treatment with collagenase cream. METHODS: Fourteen patients were selected to be treated with vegetal biomembrane and 7 with Fibrase®(CONTROL), followed clinically and photographically by the Wound Healing Index by ImageJ during 120 days and biopsied on the 1st and 30th days for histological examination. RESULTS: The vegetal biomembrane was better in promoting healing of the ulcers, especially on the inflammatory phase, confirmed by abundant exudation and wound debridement than the CONTROL group, on the 30th day. There was a greater tendency to angiogenesis followed by re-epithelialization with highest wound healing index on the 90th and 120th days. CONCLUSION: A combined analysis of clinical and histopathological findings suggests that the vegetal biomembrane acted as a factor inducing wound healing, especially on the inflammatory phase, confirmed by abundant exudation of the lesions promoting the transformation of the microenvironment of the chronic venous ulcers, and also stimulating angiogenesis and subsequent re-epithelialization.

【 授权许可】

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