Enhancement of solubility of albendazole by complexation with β-cyclodextrin

Brazilian Journal of Chemical Engineering

C. Moriwaki²  G. L. Costa²  C. N. Ferracini²  F. F. De Moraes¹  G. M. Zanin¹  E. A. G. Pineda¹  G. Matioli² 

[1] ,Universidade Estadual de Maringá Departamento de Farmácia e Farmacologia Maringá PR ,Brasil

关键词: Albendazole;    Cyclodextrins;    β-cyclodextrin;    Complexation;    Solubility;   

DOI  :  10.1590/S0104-66322008000200005

来源: SciELO

【 摘 要 】

A high dosage of albendazole (ABZ) is required for treating systemic helminthe infections because of its low solubility. Aiming at increasing ABZ solubility, complexation with beta-cyclodextrin (β-CD) using aqueous and acetic acid solutions as ABZ solubilizer was studied. In aqueous β-CD, complexation increased solubility 53.4 times, giving a complex equilibrium constant of 1266 L mol-1 with a maximum ABZ concentration of 276 µmol L-1 for 16.3 mmol L-1 β-CD. For complexation in 1.05 mol L-1 acetic acid, UV absorbance spectra and ¹H-NMR analysis confirmed complex formation. The UV absorbance of ABZ/acid acetic/β-CD solutions was modeled by the formation of two complexes with molar ratios 1:1 and 1:2 ABZ:β-CD. When neutralized with NaOH these solutions did not form precipitates only for the ABZ:β-CD molar ratios of 1:8 and 1:10, showing that ABZ solubility could be increased 306 times. Results show that high β-CD molar ratios hold ABZ in solution by complexation enhanced by the acetate anion.

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