Revista da Associação Médica Brasileira | |
Trends of 9,416 multidrug-resistant Gram-negative bacteria | |
Viviane Decicera Colombo Oliveira1  Fernando Góngora Rubio1  Margarete Teresa Gottardo Almeida1  Mara Corrêa Lelles Nogueira1  Antonio Carlos Campos Pignatari1  | |
关键词: Gram-negative bacteria; drug resistance; microbial; hospitals; university; bactérias Gram-negativas; resistência microbiana a medicamentos; hospitais universitários; | |
DOI : 10.1590/1806-9282.61.03.244 | |
来源: SciELO | |
【 摘 要 】
Summary Objective: a resistance of hospital-acquired bacteria to multiple antibiotics is a major concern worldwide. The objective of this study was to investigate multidrugresistant (MDR) bacteria, clinical specimens, origin of specimen and trends, and correlate these with bacterial sensitivity and consumption of antimicrobials. Methods: 9,416 bacteria of nosocomial origin were evaluated in a tertiary hospital, from 1999 to 2008. MDR was defined for Gram-negative bacteria (GNB) as resistance to two or more classes/groups of antibiotics. Results: GNB MDR increased by 3.7 times over the study period (p<0.001). Acinetobacter baumannii was the most prevalent (36.2%). Over the study period, there were significant 4.8-fold and 14.6-fold increases for A. baumannii and K. pneumoniae (p<0.001), respectively. Sixty-seven percent of isolates of MDR GNB were isolated in intensive care units. The resistance of A. baumannii to carbapenems increased from 7.4 to 57.5% during the study period and concomitant with an increased consumption. Conclusion: that decade showed prevalence of GNB and a gradual increase in MDR GNB. There was an increase in carbapenem resistance of 50.1% during the study.
【 授权许可】
CC BY-NC
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