Association of family risk and lifestyle/comorbidities in ovarian cancer patients

Revista da Associação Médica Brasileira

Natália Teixeira¹  Maria Aparecida Azevedo Koike Folgueira¹  Simone Maistro¹  Giselly Encinas¹  Geertruida Hendrika De Bock¹  Maria Del Pilar Estevez Diz¹ 

关键词: ovarian neoplasms;    hereditary breast and ovarian cancer syndrome;    neoplastic syndromes;    hereditary;    risk factors;    neoplasias ovarianas;    fatores de risco;    síndromes neoplásicas hereditárias;   

DOI  :  10.1590/1806-9282.61.03.234

来源: SciELO

【 摘 要 】

Summary Objectives: to analyze factors that might indicate familial predisposition for ovarian cancer in patients diagnosed with this disease. Methods: in a prospective single center cohort study at the Institute of Cancer of the State of São Paulo (ICESP), 51 women diagnosed with ovarian cancer were included. Familial predisposition for ovarian cancer was defined as having a higher than 10% chance of having a BRCA1/2 mutation according to the Manchester scoring system, a validated method to assess the likelihood of mutation detection. Each patient was interviewed with a standardized questionnaire on established risk factors for ovarian cancer and other factors that might influence the risk to develop ovarian cancer. Logistic regression analyses were performed to estimate the impact of the evaluated factors on the likelihood of mutation detection, by calculating odds ratios and 95% confidence intervals. Results: seventeen out of 51 patients had a family history of breast and/or ovarian cancer, four patients had a history of breast or endometrial cancer, 11 were diagnosed before the age of 50, and 12 presented a risk of familial predisposition to ovarian cancer higher than 10%. Patients with comorbidities, such as hypertension, diabetes, hormonal disorders, dyslipidemia and psychiatric conditions, presented a lower chance of having a familial predisposition for ovarian cancer (OR: 0.22; 95% CI: 0.06-0.88; p=0.03). Conclusion: in this study, having comorbidities was associated with a lower risk of having a familial predisposition for ovarian cancer. Other factors associated with the risk of ovarian cancer did not have an impact on this predisposition.

【 授权许可】

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