Inflammatory biomarker kinetics after mechanical and bioprosthetic valve replacement

Revista da Associação Médica Brasileira

Marcelo Rodrigues Bacci¹  Neif Murad¹  João Roberto Breda¹  Amanda Voltareli Cesar De Oliveira¹  Nathan Herszkowics¹  Nathalia Kitamoto Cardoso¹  Fernando Luiz Affonso Fonseca¹ 

关键词: interleukin-6;    heart failure;    aortic valve stenosis;    heart valve prosthesis;    insuficiência cardíaca;    estenose da valva aórtica;    interleucina-6;    bioprótese;   

DOI  :  10.1590/1806-9282.61.01.058

来源: SciELO

【 摘 要 】

Introduction: valve disease is an important cause of heart failure. There is a direct relationship between valve deterioration and the patient’s inflammatory status and cytokines: interleukin-6, interleukin-1, tumor necrosis factor, and C-reactive protein, involved in this major state of inflammation. Objective: to report a series of cases of valve replacement, using a bioprosthetic or mechanical valve, and the inflammatory profile of them. Methods: patients older than 18 years and with bioprosthetic or mechanical valve placed for a minimum of 6 months and maximum of 2 years were included. In addition to the demographic characteristics of each patient, inflammatory markers were measured and a comparison was made of echocardiographic results before (based on medical records) and after surgery. A total of 46 patients were enrolled, 23 with mechanical valve and 23 with bioprosthetic valve. Results: of the 46 patients, 20 presented complete data were included, 12 with bioprosthetic and 8 with mechanical valve. There was no difference between types of prosthesis or implant site for the values of inflammatory markers although they were all above reference range. Discussion: patients undergoing aortic mechanical valve implant benefited more than those undergoing bioprosthetic implant and both with much better results than those of valve replacements performed on mitral valve. In short, there was no difference in relation to inflammatory biomarkers.

【 授权许可】

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