Serum magnesium and proton-pump inhibitors use: a cross-sectional study

Revista da Associação Médica Brasileira

Gustavo Adolpho Moreira Faulhaber²  Bruna Maria Ascoli²  Adriano Lubini¹  Márcio Mossmann¹  Gabriela Rossi¹  Guilherme Geib¹  Tânia Weber Furlanetto² 

[1] ,Universidade Federal do Rio Grande do Sul Postgraduate Program in Medicine Porto Alegre RS ,Brazil

关键词: Magnesium;    Proton pump inhibitors;    Magnésio;    Inibidores da bomba de prótons;   

DOI  :  10.1016/j.ramb.2012.12.007

来源: SciELO

【 摘 要 】

OBJECTIVE: The aim of this study was to evaluate the association of serum magnesium levels with proton pump inhibitors (PPIs) use and other factors. METHODS: This was a cross-sectional study of 151 patients admitted with acute diseases in the Internal Medicine Division of the Hospital de Clinicas de Porto Alegre, after the exclusion of conditions that are commonly associated with hypomagnesemia: diarrhea; vomiting; chronic alcohol use; severely uncompensated diabetes mellitus; and chronic use of laxatives, diuretics or other drugs causing magnesium deficiency. RESULTS: All patients had normal serum magnesium levels. Serum albumin and creatinine levels were positively associated with serum magnesium levels, after adjusting for confounders. There was no difference between mean serum magnesium levels of PPI users and non-users, nor between men and women; there was also no correlation among age, serum phosphorus, and potassium levels with serum magnesium levels. Limitations of this study include the absence of an instrument for measuring adherence to PPI use and the sample size. CONCLUSION: The association of PPI use and hypomagnesemia is uncommon. Congenital defects in the metabolism of magnesium may be responsible for hypomagnesemia in some patients using this drug class.

【 授权许可】

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