期刊论文详细信息
Revista da Associação Médica Brasileira | |
Glucose disturbances in non-diabetic patients receiving acute treatment with methylprednisolone pulses | |
Hector Eloy Tamez Perez2  María Dolores Gómez De Ossio1  Dania Lizet Quintanilla Flores1  Mayra Ivonne Hernández Coria1  Alejandra Lorena Tamez Peña1  Gissén Jazmín Cuz Pérez1  Stephanie Lissette Proskauer Peña1  | |
[1],Universidad Autónoma de Nuevo León College of Medicine Subdivision of InvestigationMonterrey NL ,Mexico | |
关键词: Methylprednisolone; diabetes mellitus; hyperglycemia; Metilprednisolona; diabetes mellitus; hiperglicemia; | |
DOI : 10.1590/S0104-42302012000100025 | |
来源: SciELO | |
【 摘 要 】
OBJECTIVE: Methylprednisolone pulses are used in a variety of disease conditions, both for acute and chronic therapy. Although well tolerated, they increase glucose levels in both non-diabetic and diabetic patients. They may also be considered a significant risk for acute metabolic alterations. The purpose of this report is to determine the metabolic changes in blood glucose levels in non-diabetic patients receiving methylprednisolone pulses and identify the presence of predictive factors for its development. METHODS: Observational, prospective study in 50 non-diabetic patients receiving 1 g intravenous methylprednisolone pulses for three consecutive days as an indication for diverse autoimmune disorders. Demographic, anthropometric, and metabolic variables were analyzed, and glucose, insulin and C-peptide levels after each steroid pulse were identified. Different variables and the magnitude of hyperglycemia were analyzed using Pearson's correlation. RESULTS: 50 patients were included, predominantly women (66%, n = 33). The average age was 41 ± 14 years with a BMI of 26 ± 3 kg/m². Baseline glucose was 83 ± 10 mg/dL. After each steroid pulse, glucose increased to 140 ± 28, 160 ± 38 and 183 ± 44, respectively (p < 0.001). C-peptide and insulin concentrations increased significantly (p < 0.001). The prevalence of fasting hyperglycemia after each pulse was 68%, 94% and 98%, respectively. We found no correlation between the magnitude of hyperglycemia and the studied variables. CONCLUSION: Methylprednisolone pulses produced significant increases in fasting glucose in most patients without diabetes. Further studies are needed to define its role in long-term consequences.【 授权许可】
CC BY-NC
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202005130126342ZK.pdf | 194KB | download |