What should we know about metabolic syndrome and lipodystrophy in AIDS?

Revista da Associação Médica Brasileira

Dario Jose Hart Pontes Signorini²  Michelle Carreira Miranda Monteiro¹  Marion De Fátima Castro De Andrade¹  Dario Hart Signorini¹  Walter De Araújo Eyer-silva¹ 

[1] ,Fiocruz Escola Nacional de Saúde Pública

关键词: Metabolic syndrome X;    antiretroviral therapy;    highly active;    HIV-associated lipodystrophy syndrome;    HIV;    risk factors;    cross-sectional studies;    Fatores de risco;    síndrome de lipodistrofia associada ao HIV;    terapia antirretroviral de alta atividade;    HIV;    síndrome X metabólica;    estudos transversais;   

DOI  :  10.1590/S0104-42302012000100017

来源: SciELO

【 摘 要 】

OBJECTIVE: Prevalence of chronic complications of HIV infection is increasing and early recognition and treatment of the components of metabolic syndrome (MS) are essential to prevent cardiovascular and metabolic complications. Considering this, we performed a cross-sectional study on the prevalence and risk-factors for MS among HIV-infected subjects. METHODS: A total of 819 patients followed at a large outpatient HIV unit were assessed by an interviewer-administered questionnaire that recorded several demographic, epidemiologic, clinical, laboratory, and social variables. Lipodystrophy diagnosis relied on agreement between patient's self-report and physician's observation of altered body-fat deposits. The presence of three or more of the following characteristics identified MS: increased waist circumference, hypertriglyceridemia, low HDL cholesterol level, hypertension, and hyperglycemia. We used logistic regression analyses to study variables independently associated with MS. RESULTS: The prevalence of MS was 20.6% and that of lipodystrophy was 38.5%. 61 (36.1%) out of 169 patients with MS had also lipodystrophy. Patients with metabolic syndrome were significantly more likely to be older (OR = 1.08), had higher CD4 counts (OR = 1.001), had an increased body mass index (OR = 1.27) and had longer exposure to antiretroviral therapy (OR = 1.01) than those without metabolic syndrome. CONCLUSION: Both traditional risk factors for cardiovascular disease and factors associated with HIV infection itself, such as an increased CD4 cell count and a longer exposure to antiretroviral therapy, seem to be associated with metabolic syndrome in the present study population.

【 授权许可】

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