Prevalence and multiplicity of HPV in HIV women in Minas Gerais, Brazil

Revista da Associação Médica Brasileira

Christine Miranda Corrêa²  Nara Chartuni Pereira Teixeira¹  Angela Cristina Labanca De Araújo¹  Nara De Oliveira Carvalho¹  Dora Mendez Del Castillo¹  Rachel Rezende Campos¹  Isaura Vargas Oliveira¹  Antonio Rafael Alves¹  Ana Flávia De Moura França¹  Victor Hugo Melo¹ 

[1] ,Três Rios Program Atenção Integral à Saúde da Mulher Três Rios RJ ,Brazil

关键词: DNA probes;    HPV;    HIV;    polymerase chain reaction;    cervix uteri;    papillomavirus infections;    prevalence;    Sondas DNA HPV;    HIV;    reação em cadeia da polimerase;    colo do útero;    infecções por papillomavirus;    prevalência;   

DOI  :  10.1590/S0104-42302011000400017

来源: SciELO

【 摘 要 】

OBJECTIVE: To detect the frequency and subtypes of HPV in the uterine cervix of HIV-infected women. METHODS: Sample consisted of 288 HIV-infected women, recruited from the public health system of five cities of Minas Gerais, Brazil. Women were seen from August 2003 to August 2008. Cervical samples were collected for cytological analysis and for HPV DNA detection, using polymerase chain reaction (PCR). HPV DNA was classified according to its oncogenic potential in low risk (types 6, 11) and high risk (types 16, 18, 31, 33, 35). Colposcopy was performed, followed by cervical biopsy when necessary. Categorical variables were compared using the Chi-squared test, with a significance level established at the 5% level. RESULTS: HPV prevalence was 78.8%. Most frequent genotypes were HPV-6 (63.9%) and HPV-16 (48.5%). High-risk HPV were observed in 70.5% of the women; low-risk in 71.4%; both high and low-risk HPV were detected in 55.1% of the patients. Multiple HPV genotypes were detected in 64.8% of the patients; two genotypes in 23.8%, and three in 18.9%. CONCLUSION: HPV prevalence was high among HIV-infected women. Multiple HPV genotypes were common in samples from the uterine cervix of HIV-infected women

【 授权许可】

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