Evaluation of the extract of Zeyheria tuberculosa with a view to products for wound healing

Revista Latino-Americana de Enfermagem

Patrícia De Albuquerque Sarmento¹  Terezinha Da Rocha Ataíde¹  Ana Paula Fernandes Barbosa¹  João Xavier De Araújo-júnior¹  Ingrid Martins Leite Lúcio¹  Maria Lysete De Assis Bastos¹ 

关键词: Wound Healing;    Biological Assay;    Vegetal Extracts;    Microbial Sensitivity Tests;    Cicatrização;    Bioensaios;    Extratos Vegetais;    Testes de Sensibilidade Microbiana;    Cicatrización de Heridas;    Bioensayo;    Extractos de Plantas;    Pruebas de Sensibilidad Microbiana;   

DOI  :  10.1590/0104-1169.3143.2385

来源: SciELO

【 摘 要 】

OBJECTIVES:to evaluate the antimicrobial, cytotoxic and healing activities of the ethanolic extract of the stems of Z. tuberculosa via topical use and/or oral ingestion.METHOD:antimicrobial assays in vitro using the disk diffusion method, the Artemia salina toxicity test, and in vivo assays with Wistar rats. From these was collected clinical, histological and biochemical data for evaluating the healing process.RESULTS:in vitro antimicrobial testing showed activity in relation to Streptococcus pyogenes, Staphylococcus aureus and Staphylococcus epidermidis, with zones of inhibition of 18, 14 and 10 mm, respectively. The best minimum inhibitory concentration was 62.5 µg/ml for S. aureus, this bacteria being chosen for the in vitro assays. Animals treated with the ointments with the extract of Z. tuberculosa showed the best results in the reduction of the wound diameter, data confirmed by the presence of re-epithelialization in the histological samples.CONCLUSION:the extract was shown to be promising for the continuation of studies which may identify the active ingredients responsible for the pharmacological activity and its mechanism of action in the process of wound healing, so as to develop a product which may be used as an alternate means in the repair of infected cutaneous wounds.

【 授权许可】

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