The ferric aerobactin receptor IutA, a protein isolated on agarose column, is not essential for uropathogenic Escherichia coli infection

Revista Latino-Americana de Enfermagem

Taise Natali Landgraf¹  Alan Berlese¹  Fabricio Freitas Fernandes¹  Mariani Lima Milanezi¹  Roberto Martinez¹  Ademilson Panunto-castelo² 

[1] ,Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto ,Brazil

关键词: Uropathogenic Escherichia coli;    Siderophores;    Virulence;    Escherichia coli Uropatogênica;    Sideróforos;    Lectina;    Virulência;    Escherichia coli Uropatogénica;    Sideróforos;    Lectina;    Virulencia;   

DOI  :  10.1590/S0104-11692012000200017

来源: SciELO

【 摘 要 】

Although many proteins have been described involved in Escherichia coli colonization and infection, only few reports have shown lectins as important components in these processes. Because the mechanisms underlying E. coli colonization process involving lectins are not fully understood, we sought to identify the presence of other non-described lectins in E. coli. Here, we isolated a 75-kDa protein from E. coli on Sepharose column and identified it as ferric aerobactin receptor (IutA). Since IutA is controversially associated with virulence of some E. coli strains, mainly in uropathogenic E. coli (UPEC), we evaluated the presence of iutA gene in UPEC isolated from patients with urinary infection. This gene was present in only 38% of the isolates, suggesting a weak association with virulence. Because there is a redundancy in the siderophore-mediated uptake systems, we suggest that IutA can be advantageous but not essential for UPEC.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License