Hydrogen-Ion Potential of Antibiotics According to the Environment Factors Temperature and Luminosity

Revista Latino-Americana de Enfermagem

Renata Maria Coelho Crepaldi¹  Cíntia Monteiro²  Maria Angélica Sorgini Peterlini²  Mavilde Da Luz Gonçalves Pedreira² 

[1],Universidade Federal de São Paulo Departamento de EnfermagemSP ,Brazil

关键词: Pediatric Nursing;    Infusions Intravenous;    Hydrogen-Ion Concentration;    Drug Stability;    Safety;    Enfermagem Pediátrica;    Infusões Intravenosas;    Concentração de Íons de Hidrogênio;    Estabilidade de Medicamentos;    Segurança;    Enfermería Pediátrica;    Infusiones Intravenosas;    Concentración de Iones de Hidrógeno;    Estabilidad de Medicamentos;    Seguridad;   

DOI  :  10.1590/S0104-11692010000200020

来源: SciELO

【 摘 要 】

The objective of this experimental study was to measure the pH of antibiotics administered by intravenous infusion - ceftriaxone sodium, vancomycin hydrochloride, metrodinazole, penicillin G potassium and amikacin sulfate - after reconstitution with sterile water and dilution with NaCl 0.9% or dextrose 5% in water, according to temperature and luminosity of the environment. The results showed that variation in the drugs' pH was less than 1.0 value and that some antibiotics remained acidic after dilution and maintained this chemical profile in all situations studied, suggesting that the studied environmental factors did not change the solutions' acid base characteristic. Some pH values measured characterize risk for the development of chemical phlebitis and infiltration, and it is important for clinical practice to emphasize the profile of intravenous solutions of antibiotics, considering method of dilution, and time to infusion.

【 授权许可】

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