Cell-free fetal DNA in maternal plasma and noninvasive prenatal diagnosis

Revista Latino-Americana de Enfermagem

Ester Silveira Ramos¹ 

[1] ,University of Sao Paulo Medicine of Ribeirao Preto

关键词: prenatal diagnosis;    DNA;    blood;    stem cells;    blood group incompatibility;    sex;    eclampsia;    epigenesis;    ethics;    diagnóstico prenatal;    ADN;    sangre;    células madre;    incompatibilidad de grupos sanguíneos;    sexo;    eclampsia epigénesis genética;    ética;    diagnóstico pré-natal;    DNA;    sangue;    células-tronco;    incompatibilidade de grupos sanguíneos;    sexo;    eclampsia;    epigênese genética;    ética;   

DOI  :  10.1590/S0104-11692006000600020

来源: SciELO

【 摘 要 】

The noninvasive nature of the detection of fetal DNA in the maternal circulation represents the greatest advantage over the conventional methods of prenatal diagnosis. The applications of this methodology involve the detection of the fetal sex, and diagnosis, intra-uterine treatment, and evaluation of the prognosis of many diseases. Fetal cells detected in the maternal circulation have also been shown to be implicated in autoimmune diseases and to represent a potential source of stem cells. On the other hand, with the introduction of a technology that detects the fetal sex as early as at 6-8 weeks of gestation, there is the possibility of early abortion based on sex selection for social purposes. This implies an ethical discussion about the question. The introduction of new noninvasive techniques of prenatal diagnosis and the knowledge of the Nursing Team regarding new methodologies can be of great benefit to the mother and her children, and can help the Genetic Counseling of the families.

【 授权许可】

CC BY   
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