Tramadol effects on clinical variables and the mechanical nociceptive threshold in horses

Ciência Rural

Leandro Guimarães Franco²  Juan Carlos Duque Moreno¹  Antônio Raphael Teixeira Neto¹  Moisés Caetano E Souza¹  Luiz Antônio Franco Da Silva¹ 

[1] ,Universidade Estadual de Santa Cruz (UESC) Departamento de Ciências Agrárias e Ambientais (DCAA) Ilhéus BA ,Brasil

关键词: analgesia;    horse;    opioid;    von Frey device;    analgesia;    equino;    opioide;    von Frey;   

DOI  :  10.1590/S0103-84782014000300021

来源: SciELO

【 摘 要 】

This study assessed the clinical effects and the mechanical antinociceptive potential of intravenous (IV) tramadol in horses.A blinded and randomized study was designed with 7 horses treated with 1 (Tr1), 2 (Tr2) or 3 (Tr3) mg kg-1 of tramadol IV. The heart rate, respiratory rate (fR), arterial pressure, degree of sedation, gastrointestinal motility (GI), behavior changes and the mechanical nociceptive threshold (MNT) were evaluated. The MNT was determined with von Frey device method.Tr3 had a significant increase in their fR and more pronounced behavioral changes than other treatments.The Tr1 showed a significant increase in arterial pressure. The GI reduced significantly, mainly in Tr2. The tramadol did not change the MNT of the horses.The clinical alterations observed with the different treatments were considered mild and transitory, being most evident in Tr2. However the tramadol did not have any analgesic effect with any of the doses evaluated.

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