Methylene blue 1% solution on the prevention of intraperitoneal adhesion formation in a dog model

Ciência Rural

Marco Augusto Machado Silva²  Olízio Claudino Da Silva¹  Luiz Antônio Franco Da Silva¹  Raquel Cunha Ribeiro¹  Paula Marina Brito Jorge¹  Jalily Bady Helou¹  Pedro Paulo Maia Teixeira¹  Maurício Veloso Brun¹ 

[1] ,Universidade de Passo Fundo (UPF) Faculdade de Agronomia e Medicina Veterinária (FAMV) Passo Fundo RS ,Brasil

关键词: adhesions;    prophylaxis;    methylene blue;    laparoscopic assessment;    surgical trauma;    bitches;    aderências;    profilaxia;    azul de metileno;    avaliação laparoscópica;    trauma cirúrgico;    cadelas;   

DOI  :  10.1590/S0103-84782013005000114

来源: SciELO

【 摘 要 】

Intraperitoneal adhesions usually are formed after abdominal surgeries and may cause technical difficulties during surgical intervention, chronic abdominal pain and severe obstructions of the gastrointestinal tract. The current study aimed to evaluate the efficacy of methylene blue (MB) 1% solution on the prevention of intraperitoneal postsurgical adhesion formation in a canine surgical trauma model. Twenty bitches were submitted to falciform ligament resection, omentectomy, ovariohysterectomy and scarification of a colonic segment. Prior to abdominal closure, 10 bitches received 1mg kg-1 MB intraperitoneally (MB group) and 10 bitches received no treatment (control group, CT). On the 15th postoperative day the bitches were submitted to laparoscopy to assess adhesions. The mean adhesion scores were 13.9 (±5.6) for MB group and 20.5 (±6.4) for the CT group (P=0,043). In conclusion, the 1% MB solution was efficient on the prevention of intraperitoneal postoperative adhesion formation in bitches, especially those involving the colonic serosa.

【 授权许可】

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