Osteonecrosis Related to Once-Yearly Zoledronic Acid Treatment in anOsteoporotic Patient after Dental Implant

Brazilian Dental Journal

Thais Gimenez Miniello¹  Juliane Pirágine Araújo¹  Rodrigo Nascimento Lopes¹  Fabio Abreu Alves¹ 

关键词: osteonecrosis of the jaw;    bisphosphonate-associated osteonecrosis;    once-yearly zoledronic acid;    dental implants.;   

DOI  :  10.1590/0103-6440201300255

来源: SciELO

【 摘 要 】

This paper presents a case of osteonecrosis of the jaw related to zoledronic acid (5mg) administered once yearly to treat osteoporosis. A 79-year-old woman who has beentreated for osteoporosis for 5 years with 5 applications of zoledronic acid wasreferred for evaluation. The patient had been submitted to dental implant placementand there was no osseointegration. On clinical examination, suppuration and exposedbone on the alveolar ridge were observed. Radiographic examination revealed anosteolytic area and bone sequestration. Both clinical and radiological features weresuggestive of osteonecrosis. The treatment consisted of surgery to remove theaffected bone completely. The patient is asymptomatic at 9 months after surgery.Dentists and oral surgeons should be alert to the possibility of osteonecrosisrelated to the use of once-yearly injections of zoledronic acid for the treatment ofpostmenopausal osteoporosis.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License