Brazilian Dental Journal | |
Wilms tumor 1 protein is not expressed in oral lymphangiomas | |
Ana Carolina De Mesquita Netto1  Mariana Batista De Oliveira1  Vanessa Fátima Bernardes1  Carolina Cavaliéri Gomes1  Ricardo Santiago Gomez1  | |
[1] ,Universidade Federal de Minas GeraisBelo Horizonte MG ,Brazil | |
关键词: oral lymphangioma; WT1; Wilms tumor 1; | |
DOI : 10.1590/S0103-64402012000600014 | |
来源: SciELO | |
【 摘 要 】
Lymphangiomas are benign hamartomatous lesions of lymphatic vessels. Wilms Tumor 1 (WT1) is a transcription factor that is activated in some human neoplasias. WT1 protein expression is observed in endothelial cells during angiogenesis and is a useful marker to distinguish between vascular proliferations and vascular malformations. The purpose of the present study is to report a case series of oral lymphangiomas together with an immunohistochemical investigation of WT1. Seventeen cases of oral lymphangioma were retrieved and reviewed. Immunohistochemical analysis of WT1 protein was performed and pyogenic granuloma samples were used as positive controls. The male/female ratio was 1.125 and most of the lesions occurred in young subjects. While pyogenic granuloma showed positive staining for WT1, the endothelial cells lining the thin-walled dilated lymphatic vessels of lymphangiomas were negative for this protein. The findings strengthen the idea that oral lymphangioma is a vascular malformation characterized by lymphatic dilatation without significant endothelial proliferation.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
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RO202005130109870ZK.pdf | 886KB | download |