Steroidal and non-steroidal cyclooxygenase-2 inhibitor anti-inflammatory drugs as pre-emptive medication in patients undergoing periodontal surgery

Brazilian Dental Journal

Maria Fernanda Santos Peres¹  Fernanda Vieira Ribeiro¹  Karina Gonzalez Silvério Ruiz¹  Francisco Humberto Nociti-jr¹  Enilson Antônio Sallum¹  Márcio Zaffalon Casati¹ 

[1] ,University of Campinas Piracicaba Dental School Department of Prosthodontics and PeriodonticsPiracicaba SP ,Brazil

关键词: anti-inflammatory;    pre-emptive drugs;    periodontal surgery;    crown lengthening;   

DOI  :  10.1590/S0103-64402012000600001

来源: SciELO

【 摘 要 】

The aim of the present study was to compare the pre-emptive use of a cyclooxygenase-2 (COX-2) inhibitor with a well established steroidal anti-inflammatory drug for pain and edema relief following periodontal surgery for crown lengthening. Thirty patients requiring periodontal surgery were randomly assigned to receive one of the following medications: selective COX-2 inhibitor or steroidal anti-inflammatory drug, 60 min before the surgical procedure. To examine patient anxiety, a Corah's dental anxiety scale was applied before surgery. Using a visual analog scale, the extent of pain/discomfort during the trans-operative period and immediately after the surgery was measured. Additionally, intensity of pain/discomfort and edema were examined 4, 8, 12 and 24 h postoperatively. With regard to anxiety, no statistical differences between the groups were observed (p>0.05). With respect to the extent of pain/discomfort during the trans-operative, immediate and late postoperative period, data demonstrated no significant differences (p>0.05) between the COX-2 inhibitor and steroidal groups. With regard to edema, intragroup analysis did not reveal any statistically significant difference (p>0.05) during the 24 h following surgery in either group. In conclusion, both anti-inflammatory drugs presented a similar potential for pain and edema relief following periodontal surgery.

【 授权许可】

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