Cell proliferation and apoptosis in ameloblastomas and keratocystic odontogenic tumors

Brazilian Dental Journal

Fabrício Rezende Amaral²  Gláucia Cardoso Paixão Mateus²  Lucas Alves Bonisson²  Bruno Augusto Benevenuto De Andrade²  Ricardo Alves Mesquita¹  Martinho Campolina Rebello Horta²  Helenice De Andrade Marigo² 

[1] ,Pontifical Catholic University of Minas Gerais Department of Dentistry Belo Horizonte MG ,Brazil

关键词: cell proliferation;    apoptosis;    ameloblastoma;    odontogenic keratocyst;   

DOI  :  10.1590/S0103-64402012000200001

来源: SciELO

【 摘 要 】

A high proliferative activity of the odontogenic epithelium in ameloblastoma (AM) and keratocystic odontogenic tumor (KOT) has been demonstrated. However, no previous study has simultaneously evaluated cell proliferation and apoptotic indexes in AM and KOT, comparing both lesions. The aim of this study was to assess and compare cell proliferation and apoptotic rates between these two tumors. Specimens of 11 solid AM and 11 sporadic KOT were evaluated. The proliferation index (PI) was assessed by immunohistochemical detection of Ki-67 and the apoptotic index (AI) by methyl green-pyronine and in situ DNA nick end-labelling methods. KOT presented a higher PI than AM (p<0.05). No statistically significant difference was found in the AI between AM and KOT. PI and AI were higher in the peripheral cells of AM and respectively in the suprabasal and superficial layers of KOT. In conclusion, KOT showed a higher cell proliferation than AM and the AI was similar between these tumors. These findings reinforce the classification of KOT as an odontogenic tumor and should contribute to its aggressive clinical behavior.

【 授权许可】

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