Subcutaneous connective tissue response to primary root canal filling materials

Brazilian Dental Journal

Alexandra Mussolino De Queiroz¹  Sada Assed¹  Alberto Consolaro¹  Paulo Nelson-filho¹  Mario Roberto Leonardo¹  Raquel Assed Bezerra Silva¹  Lea Assed Bezerra Silva¹ 

[1] ,University of São Paulo Ribeirão Preto Dental School Department of Pediatric Clinics, Preventive and Community DentistryRibeirão Preto SP ,Brazil

关键词: root filling materials;    primary teeth;    tissue response;    subcutaneous tissue;   

DOI  :  10.1590/S0103-64402011000300005

来源: SciELO

【 摘 要 】

This study evaluated the response of the subcutaneous connective tissue of BALB/c mice to root filling materials indicated for primary teeth: zinc oxide/eugenol cement (ZOE), Calen paste thickened with zinc oxide (Calen/ZO) and Sealapex sealer. The mice (n=102) received polyethylene tube implants with the materials, thereby forming 11 groups, as follows: I, II, III: Calen/ZO for 7, 21 and 63 days, respectively; IV, V, VI: Sealapex for 7, 21 and 63 days, respectively; VII, VIII, IX: ZOE for 7, 21 and 63 days, respectively; X and XI: empty tube for 7 and 21 days, respectively. The biopsied tissues were submitted to histological analysis (descriptive analysis and semi-quantitative analysis using a scoring system for collagen fiber formation, tissue thickness and inflammatory infiltrate). A quantitative analysis was performed by measuring the area and thickness of the granulomatous reactionary tissue (GRT). Data were analyzed by Kruskal-Wallis, ANOVA and Tukey's post-hoc tests (?=0.05). There was no significant difference (p>0.05) among the materials with respect to collagen fiber formation or GRT thickness. However, Calen/ZO produced the least severe inflammatory infiltrate (p<0.05). The area of the GRT was significantly smaller (p<0.05) for Calen/ZO and Sealapex. In conclusion, Calen/ZO presented the best tissue reaction, followed by Sealapex and ZOE.

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