Biocompatibility of four root canal sealers: a histopathological evaluation in rat subcutaneous connective tissue

Brazilian Dental Journal

Camila Maggi Maia Silveira¹  Shelon Cristina Souza Pinto¹  Rosário De Arruda Moura Zedebski¹  Fábio André Santos¹  Gibson Luiz Pilatti¹ 

[1] ,Ponta Grossa State University Department of Dentistry Ponta Grossa PR ,Brazil

关键词: biocompatibility testing;    connective tissue cells;    rats;   

DOI  :  10.1590/S0103-64402011000100003

来源: SciELO

【 摘 要 】

The aim of this study was to evaluate the subcutaneous biocompatibility of: Epiphany, AH Plus, Pulp Canal Sealer and Sealapex root canal sealers. Sixty rats were randomly assigned to 4 groups, according to the sealer. Polyethylene tubes containing the tested materials were inserted into the connective tissue. The implants were removed after 7, 15 and 30 days, and the tissue samples were processed, stained and examined by light microscopy. The descriptive analysis considered: thickness of the fibrous capsule, severity of the inflammatory reaction, and presence of giant cells. After 7 days, all sealers induced moderate to severe inflammatory reaction. After 15 days, Epiphany and AH Plus sealers showed a moderate inflammatory reaction, while Pulp Canal Sealer and Sealapex induced severe and mild inflammatory reactions, respectively. After 30 days, mild inflammatory reactions were observed for Epiphany, Sealapex and AH Plus. Sealapex induced the lowest inflammatory response at all evaluation periods, and only Pulp Canal Sealer did not show a decreased in the inflammatory reaction over time.

【 授权许可】

CC BY   
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