Synthesis and biocompatibility of an experimental glass ionomer cement prepared by a non-hydrolytic sol-gel method

Brazilian Dental Journal

Lucas Da Fonseca Roberti Garcia²  Fernanda De Carvalho Panzeri Pires-de-souza²  Juliana Mazzoneto Teófilo²  Alexandre Cestari¹  Paulo Sergio Calefi¹  Katia Jorge Ciuffi¹  Eduardo José Nassar¹ 

[1] ,University of São Paulo Ribeirão Preto Dental School Department of Dental Materials and ProsthodonticsRibeirão Preto SP ,Brazil

关键词: glass ionomer cement;    sol-gel synthesis;    biocompatibility;    dental materials;   

DOI  :  10.1590/S0103-64402010000600004

来源: SciELO

【 摘 要 】

The aims of this study were to demonstrate the synthesis of an experimental glass ionomer cement (GIC) by the non-hydrolytic sol-gel method and to evaluate its biocompatibility in comparison to a conventional glass ionomer cement (Vidrion R). Four polyethylene tubes containing the tested cements were implanted in the dorsal region of 15 rats, as follows: GI - experimental GIC and GII - conventional GIC. The external tube walls was considered the control group (CG). The rats were sacrificed 7, 21 and 42 days after implant placement for histopathological analysis. A four-point (I-IV) scoring system was used to graduate the inflammatory reaction. Regarding the experimental GIC sintherization, thermogravimetric and x-ray diffraction analysis demonstrated vitreous material formation at 110oC by the sol-gel method. For biocompatibility test, results showed a moderate chronic inflammatory reaction for GI (III), severe for GII (IV) and mild for CG (II) at 7 days. After 21 days, GI presented a mild reaction (II); GII, moderate (III) and CG, mild (II). At 42 days, GI showed a mild/absent inflammatory reaction (II to I), similar to GII (II to I). CG presented absence of chronic inflammatory reaction (I). It was concluded that the experimental GIC presented mild/absent tissue reaction after 42 days, being biocompatible when tested in the connective tissue of rats.

【 授权许可】

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